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Avoid Marijuana If You Take These Prescription Drugs or substances: Drug Interactions

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According to the Drug Enforcement Agency (D.E.A.), there are no known cases of marijuana overdose deaths when taken alone.1 However, there are some harmful drug interactions when taking cannabis in a combination with other prescription drugs and substances.

We searched “cannabis” in the drug interaction checker on Drugs.com and found a total of 333 drugs are known to interact with cannabis. There are 24 major and 309 moderate interactions. Here is a list of major and moderate drug interactions when taken with cannabis. Consult with your healthcare provider to ensure all your medication is safe to take with marijuana. Contact your physician if you are taking any of the following drugs with cannabis. Call 911 if you are having a medical emergency.

Major Drug Interactions

Alfentanil
Buprenorphine
Butorphanol
Codeine
Dezocine
Fentanyl
Hydrocodone
Hydromorphone
Levomethadyl acetate
Levorphanol
Meperidine
Methadone
Morphine
Morphine liposomal
Nalbuphine
Oxycodone
Oxymorphone
Pentazocine
Propoxyphene
Remifentanil
Sodium oxybate
Sufentanil
Tapentadol
Tramadol

Moderate Drug Interactions

acebutolol
acetylcarbromal
aldesleukin
alfuzosin
alprazolam
amiloride
aminophylline
amitriptyline
amlodipine
amobarbital
amoxapine
amyl nitrite
apomorphine
apraclonidine ophthalmic
aripiprazole
asenapineatenolol
azatadine
azelastine nasal
benazepril
bendroflumethiazide
benzthiazide
benztropine
bepridil
betaxolol
biperiden
bisoprolol
brexanolone
brexpiprazole
brimonidine ophthalmic
brimonidine topical
brivaracetam
bromocriptine
brompheniramine
bumetanide
buspirone
butabarbital
butalbital
candesartan
cannabidiol
captopril
carbamazepine
carbetapentane
carbinoxamine
cariprazine
carisoprodol
carteolol
carvedilol
cetirizine
chlophedianol
chloral hydrate
chlorcyclizine
chlordiazepoxide
chlormezanone
chlorothiazide
chlorphenesin
chlorpheniramine
chlorpromazine
chlorthalidone
chlorzoxazone
citalopram
clemastine
clevidipine
clobazam
clomipramine
clonazepam
clonidine
clorazepate
clozapine
cyclizine
cyclobenzaprine
cyproheptadine
dantrolenea
deserpidine
desipramine
desvenlafaxine
deutetrabenazine
dexbrompheniramine
dexchlorpheniramine
dexmedetomidine
dextromethorphan
diazepam
diazoxide
diltiazem
dimenhydrinate
diphenhydramine
divalproex sodium
doxazosin
doxepin
doxepin topical
doxylamine
dronabinol
droperidol
duloxetine
entacapone
eplerenone
eprosartan
esketamine
eslicarbazepine
estazolam
eszopiclone
ethacrynic acid
ethanol
ethchlorvynol
ethosuximide
ethotoin
ezogabine
felbamate
felodipine
fenoldopam
flavoxate
flibanserin
fluoxetine
fluphenazine
fluvoxamine
fosinopril
fosphenytoin
fospropofol
furosemide
guanabenz
guanadrel
guanethidine
guanfacine
halazepam
heroin
haloperidol
hydralazine
hydrochlorothiazide
hydroflumethiazide
hydroxyzine
ifosfamide
iloperidone
imipramine
indapamide
irbesartan
isocarboxazid
isosorbide dinitrate
isosorbide mononitrate
isradipine
kava
ketamine
labetalol
lamotrigine
lapatinib
levetiracetam
levocetirizine
lisinopril
lithium
lofexidine
lorazepam
losartan
loxapine
lurasidone
maprotiline
meclizine
mephenytoin
mephobarbital
meprobamate
mesoridazine
metaxalone
methdilazine
methocarbamol
methotrimeprazine
methsuximide
methyclothiazide
methyldopa
metoclopramide
metolazone
metoprolol
metyrosine
mibefradil
midazolam
mirtazapine
moexipril
molindone
nabilone
nadolol
nebivolol
nefazodone
nicardipine
nifedipine
nimodipine
nisoldipine
nitroglycerin
nitroprusside
nortriptyline
olanzapine
olmesartan
olopatadine nasal
opium
orphenadrine
oxazepam
oxcarbazepine
oxtriphylline
paliperidone
paraldehyde
paramethadione
paroxetine
penbutolol
pentobarbital
perampanel
pergolide
perindopril
perphenazine
phenacemide
phenelzine
phenindamine
phenobarbital
phenoxybenzamine
phensuximide
phentolamine
phenytoin
pimozide
pindolol
pramipexole
polythiazide
prazosin
pregabalin
primidone
prochlorperazine
procyclidine
promazine
promethazine
propiomazine
propofolpropranolol
protriptyline
pyrilamine
quazepam
quetiapine
quinapril
ramelteon
ramipril
rasagiline
rauwolfia serpentina
reserpine
ropinirole
rotigotine
rufinamide
secobarbital
sertraline
sibutramine
silodosin
sirolimus
sotalol
spironolactone
st. john’s wort
stiripentol
suvorexant
tacrolimus
tamsulosin
tasimelteon
telmisartan
temazepam
terazosin
tetrabenazine
thalidomide
theophylline
thiethylperazine
thiopental
thioridazine
thiothixene
tiagabine
timolol
tizanidine
tolcapone
topiramate
torsemide
trandolapril
tranylcypromine
trazodone
triamterene
triazolam
trichlormethiazide
trifluoperazine
triflupromazine
trihexyphenidyl
trimeprazine
trimethadione
trimethaphan camsylate
trimethobenzamide
trimipramine
tripelennamine
triprolidine
valbenazine
valerian
valproic acid
valsartan
venlafaxine
vigabatrin
warfarin
zaleplon
ziconotide
ziprasidone
zolpidem
zonisamide

*MEDICAL DISCLAIMER
This may not a complete list of possible drug interactions. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Weed Times does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

1https://doh.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/Medical%20Cannabis%20Adverse%20Effects%20and%20Drug%20Interactions_0.pdf
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Related Topics
  • drug interactions
  • marijuana interactions
  • prescription drugs
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