According to the Drug Enforcement Agency (D.E.A.), there are no known cases of marijuana overdose deaths when taken alone.1 However, there are some harmful drug interactions when taking cannabis in a combination with other prescription drugs and substances.
We searched “cannabis” in the drug interaction checker on Drugs.com and found a total of 333 drugs are known to interact with cannabis. There are 24 major and 309 moderate interactions. Here is a list of major and moderate drug interactions when taken with cannabis. Consult with your healthcare provider to ensure all your medication is safe to take with marijuana.
Major Drug Interactions
| Alfentanil |
| Buprenorphine |
| Butorphanol |
| Codeine |
| Dezocine |
| Fentanyl |
| Hydrocodone |
| Hydromorphone |
| Levomethadyl acetate |
| Levorphanol |
| Meperidine |
| Methadone |
| Morphine |
| Morphine liposomal |
| Nalbuphine |
| Oxycodone |
| Oxymorphone |
| Pentazocine |
| Propoxyphene |
| Remifentanil |
| Sodium oxybate |
| Sufentanil |
| Tapentadol |
| Tramadol |
Moderate Drug Interactions
| acebutolol |
| acetylcarbromal |
| aldesleukin |
| alfuzosin |
| alprazolam |
| amiloride |
| aminophylline |
| amitriptyline |
| amlodipine |
| amobarbital |
| amoxapine |
| amyl nitrite |
| apomorphine |
| apraclonidine ophthalmic |
| aripiprazole |
| asenapineatenolol |
| azatadine |
| azelastine nasal |
| benazepril |
| bendroflumethiazide |
| benzthiazide |
| benztropine |
| bepridil |
| betaxolol |
| biperiden |
| bisoprolol |
| brexanolone |
| brexpiprazole |
| brimonidine ophthalmic |
| brimonidine topical |
| brivaracetam |
| bromocriptine |
| brompheniramine |
| bumetanide |
| buspirone |
| butabarbital |
| butalbital |
| candesartan |
| cannabidiol |
| captopril |
| carbamazepine |
| carbetapentane |
| carbinoxamine |
| cariprazine |
| carisoprodol |
| carteolol |
| carvedilol |
| cetirizine |
| chlophedianol |
| chloral hydrate |
| chlorcyclizine |
| chlordiazepoxide |
| chlormezanone |
| chlorothiazide |
| chlorphenesin |
| chlorpheniramine |
| chlorpromazine |
| chlorthalidone |
| chlorzoxazone |
| citalopram |
| clemastine |
| clevidipine |
| clobazam |
| clomipramine |
| clonazepam |
| clonidine |
| clorazepate |
| clozapine |
| cyclizine |
| cyclobenzaprine |
| cyproheptadine |
| dantrolenea |
| deserpidine |
| desipramine |
| desvenlafaxine |
| deutetrabenazine |
| dexbrompheniramine |
| dexchlorpheniramine |
| dexmedetomidine |
| dextromethorphan |
| diazepam |
| diazoxide |
| diltiazem |
| dimenhydrinate |
| diphenhydramine |
| divalproex sodium |
| doxazosin |
| doxepin |
| doxepin topical |
| doxylamine |
| dronabinol |
| droperidol |
| duloxetine |
| entacapone |
| eplerenone |
| eprosartan |
| esketamine |
| eslicarbazepine |
| estazolam |
| eszopiclone |
| ethacrynic acid |
| ethanol |
| ethchlorvynol |
| ethosuximide |
| ethotoin |
| ezogabine |
| felbamate |
| felodipine |
| fenoldopam |
| flavoxate |
| flibanserin |
| fluoxetine |
| fluphenazine |
| fluvoxamine |
| fosinopril |
| fosphenytoin |
| fospropofol |
| furosemide |
| guanabenz |
| guanadrel |
| guanethidine |
| guanfacine |
| halazepam |
| heroin |
| haloperidol |
| hydralazine |
| hydrochlorothiazide |
| hydroflumethiazide |
| hydroxyzine |
| ifosfamide |
| iloperidone |
| imipramine |
| indapamide |
| irbesartan |
| isocarboxazid |
| isosorbide dinitrate |
| isosorbide mononitrate |
| isradipine |
| kava |
| ketamine |
| labetalol |
| lamotrigine |
| lapatinib |
| levetiracetam |
| levocetirizine |
| lisinopril |
| lithium |
| lofexidine |
| lorazepam |
| losartan |
| loxapine |
| lurasidone |
| maprotiline |
| meclizine |
| mephenytoin |
| mephobarbital |
| meprobamate |
| mesoridazine |
| metaxalone |
| methdilazine |
| methocarbamol |
| methotrimeprazine |
| methsuximide |
| methyclothiazide |
| methyldopa |
| metoclopramide |
| metolazone |
| metoprolol |
| metyrosine |
| mibefradil |
| midazolam |
| mirtazapine |
| moexipril |
| molindone |
| nabilone |
| nadolol |
| nebivolol |
| nefazodone |
| nicardipine |
| nifedipine |
| nimodipine |
| nisoldipine |
| nitroglycerin |
| nitroprusside |
| nortriptyline |
| olanzapine |
| olmesartan |
| olopatadine nasal |
| opium |
| orphenadrine |
| oxazepam |
| oxcarbazepine |
| oxtriphylline |
| paliperidone |
| paraldehyde |
| paramethadione |
| paroxetine |
| penbutolol |
| pentobarbital |
| perampanel |
| pergolide |
| perindopril |
| perphenazine |
| phenacemide |
| phenelzine |
| phenindamine |
| phenobarbital |
| phenoxybenzamine |
| phensuximide |
| phentolamine |
| phenytoin |
| pimozide |
| pindolol |
| pramipexole |
| polythiazide |
| prazosin |
| pregabalin |
| primidone |
| prochlorperazine |
| procyclidine |
| promazine |
| promethazine |
| propiomazine |
| propofolpropranolol |
| protriptyline |
| pyrilamine |
| quazepam |
| quetiapine |
| quinapril |
| ramelteon |
| ramipril |
| rasagiline |
| rauwolfia serpentina |
| reserpine |
| ropinirole |
| rotigotine |
| rufinamide |
| secobarbital |
| sertraline |
| sibutramine |
| silodosin |
| sirolimus |
| sotalol |
| spironolactone |
| st. john’s wort |
| stiripentol |
| suvorexant |
| tacrolimus |
| tamsulosin |
| tasimelteon |
| telmisartan |
| temazepam |
| terazosin |
| tetrabenazine |
| thalidomide |
| theophylline |
| thiethylperazine |
| thiopental |
| thioridazine |
| thiothixene |
| tiagabine |
| timolol |
| tizanidine |
| tolcapone |
| topiramate |
| torsemide |
| trandolapril |
| tranylcypromine |
| trazodone |
| triamterene |
| triazolam |
| trichlormethiazide |
| trifluoperazine |
| triflupromazine |
| trihexyphenidyl |
| trimeprazine |
| trimethadione |
| trimethaphan camsylate |
| trimethobenzamide |
| trimipramine |
| tripelennamine |
| triprolidine |
| valbenazine |
| valerian |
| valproic acid |
| valsartan |
| venlafaxine |
| vigabatrin |
| warfarin |
| zaleplon |
| ziconotide |
| ziprasidone |
| zolpidem |
| zonisamide |
*MEDICAL DISCLAIMER
This may not a complete list of possible drug interactions. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Weed Times does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.
1https://doh.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/Medical%20Cannabis%20Adverse%20Effects%20and%20Drug%20Interactions_0.pdf